Mucosal vaccination by adenoviruses displaying reovirus sigma 1

Avian reovirus sigma C enhances the mucosal and systemic immune responses elicited by antigen-conjugated lactic acid bacteria.

Mucosal surfaces are common sites of pathogen colonization/entry. Effective mucosal immunity by vaccination should provide protection at this primary infection site. Our aim was to develop a new vaccination strategy that elicits a mucosal immune response. A new strain of Enterococcus faecium, a non pathogenic lactic acid bacteria (LAB) with strong cell adhesion ability, was identified and used ...

Comparison of Systemic and Mucosal Immunization with Helper-Dependent Adenoviruses for Vaccination against Mucosal Challenge with SHIV

Most HIV-1 infections are thought to occur at mucosal surfaces during sexual contact. It has been hypothesized that vaccines delivered at mucosal surfaces may mediate better protection against HIV-1 than vaccines that are delivered systemically. To test this, rhesus macaques were vaccinated by intramuscular (i.m.) or intravaginal (ivag.) routes with helper-dependent adenoviral (HD-Ad) vectors e...

36 Expression of Reovirus Sigma C Protein in Arabidopsis

during subsequent incubation in two experiments. Treatment groups had four replicate incubation trays of 150 eggs each. As expected, hatchability of fertile eggs declined with length of egg storage in both experiments (P<0.01). This was due to increases in both percentage early and late dead embryos in both experiments. Hatchability of fertile eggs was increased by SEU storage and turning durin...

Mucosal Immunology and Oral Vaccination

The mucosal surfaces of the gastrointestinal and respiratory tracts represent the principal portals of entry for most infectious agents. Hence, the development of vaccination strategies capable of inducing protective immune responses at the mucosal sites is a priority. Since the mucosal surfaces are exposed to a wide variety of antigens, the mucosal immune system has to discriminate between har...

REOVIRUS GROWTH INHIBITION BY ROTAVIRUS FOLLOWING COINFECTION